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Movies
MOA Video, Part 1 (6.04Mb)
MOA Video, Part 1 HTML5 (6.04Mb)
MOA Video, Part 2 (8.27Mb)
MOA Video, Part 3 (9.25Mb)
Femoral Sheath Removal (31.78Mb)
Bivalirudin Core Product Profile
Angiomax CPP slides (2.59Mb PDF)
Product Monograph (6.06Mb PDF)
AHFS Fact Sheet (6.91Mb)
Strategic Initiative Reference Materials
Thrombosis/Thrombin
Heparin
Bivalirudin MOA & Pharmacology
Procedural Outcomes
Clinical Efficacy
SWITCH Strategy
Radial Access & Bivalirudin
Bridge STEMI to NSTEMI
Clopidogrel
Safety
Value
Guidelines
Important Safety Information
Thrombosis/Thrombin
Becker CV disease thrombin pathobiology biochemistry AHJ
Brummel-Ziedins ACS thrombin generation plasma factor J Thromb Haem 1.2008
Coughlin Nature 2000
Coughlin PAR vascular biology Thromb Haemost 7 2001
Croce thrombosis inflammation atherosclerosis Curr Opin Hematol 1.2007
Fuster pathogenesis CAD ACS pt 2 NEJM 1 1992
Hoffman coagulation platelets cell-based model Thromb Haem 2001
Mann thrombin ATVB 1.03
Mann thrombin formation Chest 9.03
Mirabet thrombin cell death ischemia reperfusion J Mol Cell Card 8.05
Monroe ATVB 2002
Silvain thrombus formation slides JACC 2011
Silvain thrombus formation STEMI JACC 3 2011
Yeghiazarians review unstable angina pectoris NEJM 1 2000
Heparin
Anand bivalirudin platelet function PCI AJC 8.2007
Bittl Am Heart J 2001
Chew Optimal ACT PCI Circulation 2001
Gao heparin induced platelet activation supplemental data Blood 3 2011
Gao heparin-induced platelet activation Blood 3 2011in press
Henry JIC 2002
Hirsh Chest 1995
Hirsh Chest 1998
Hirsh heparin Chest 2001
Sobel J Vasc Surg 2001
Weitz Circulation 2002
Weitz J Clin Invest 8.1990
Bivalirudin MOA & Pharmacology
Angiomax PI - 12.06.2005
Coughlin Nature 2000
Garratt Czak Bajaj Premier bivalirudin mortality non-access bleed LOS cost TCT 2010
Henry JIC 2002
Keating bivalirudin P-selectin platelet-leukocyte eptifibatide heparin Thromb Res 7.06
Keating bivalirudin UFH eptifibatide inflammation thrombin CAD 9.05
Kimmelstiel bivalirudin PAR1 PAR4 thrombin PCI platelet activation Circ Cardiovasc Interv 4.2011
Lincoff bivalirudin REPLACE-2 30-day JAMA 2.03
Logic of bivalirudin_ thrombin_heparin_bival MOA, PK 2011
Maraganore Biochem 1990
Mehta AFRICA bivalirudin sheath ambulation Cath lab Digest 2004
Robson bivalirudin renal JIC 12.2000
Schneider bivalirudin thrombin platelet activation CAD 7.06
Schneider platelet bivalirudin anticoagulants Rev Cardiovasc Med 2006
Sibbing bivalirudin ISAR REACT-3 EHJ 6.2008
Stone ACUITY study design bivalirudin AHJ 11.04
Topol Circulation 1993
Weitz bivalirudin platelet TCT Am J Cardiol 2001
Procedural Outcomes
He TCT-5 abstract HORIZONS thrombus STEMI bivalirudin Am J Cardiol 9 2009
Stone ACUITY PCI LBCT slides AHA 2006
Stone bivalirudin ACUITY 30-day NEJM 11.06
Stone bivalirudin ACUITY PCI Lancet 3.2007
Clinical Efficacy
Aoki diabetes thrombin platelet JACC1996
Feit TCT abs 507 bivalirudin 1-year mortality diabetes PCI pooled Am J Cardiol 9.2009
Garratt bivalirudin mortality reductions PCI bleeding Premier poster TCT 2010
Garratt TCT-117 mortality bleeding bivalirudin Premier PCI JACC 9 2010
GUSTO streptokinase heparin NEJM 9 1993
He TCT-5 abstract HORIZONS thrombus STEMI bivalirudin Am J Cardiol 9 2009
ISIS-2 Coll Group streptokinase oralaspirin AMI Lancet 8 1988
Kandzari metaanalysis abciximab GP IIb IIIa Am Heart J 3.04
Keeley primary PCI thrombolytic therapy AMI meta-analysis LAncet 1 2003
Mehran bivalirudin HORIZONS-AMI 1-year Lancet 10.2009
Rassen bivalirudin heparin GPIIbIIIa Premier data EHJ 3.2010
Stone bivalirudin ACUITY 1-year JAMA 12.2007
Stone bivalirudin ACUITY 30-day NEJM 11.06
Stone bivalirudin HORIZONS-AMI 30 Day NEJM 6.2008
Stone HORIZONS 3 year TCT 2010
Stone HORIZONS 3-year final report slides TCT 2010
SWITCH Strategy
Ahmed switching antithrombin therapy regional PCI center J Thromb Thrombolysis 4.2010
Astroulakis SWITCHing heparin bivalirudin bleeding ECES Summit STEMI EHJ 6 2009
Dangas HORIZONS switch ESC 8.2010
Gibson bivalirudin REPLACE-2 switch bleeding AJC 4.2007
Waksman SWITCH bivalirudin enoxaparin ACS PCI JIC 8.06
White ACUITY NSTE-ACS bivalirudin switch JACC 5.2008
Radial Access & Bivalirudin
Garratt Czak Bajaj Premier bivalirudin mortality non-access bleed LOS cost TCT 2010
Verheugt bivalirudin access site bleeding PCI JACC Intervent 2 2011
Verheugt bivalirudin non-access bleeding pooled JACC Interv 2011
Bridge STEMI to NSTEMI
Aoki diabetes thrombin platelet JACC1996
Biondi-Zoccai atherothrombosis inflammation diabetes JACC 4.03
Dangwal high glucose thrombin responses PAR4 ATVB 1 2011in press
Dangwal high glucose thrombin responses PAR4 data supplement ATVB 1 2011in press
de Jager endothelial dysfunction inflammation CV mortality diabetes type 2 Hoorn Study ATVB 5.06
Feit ACC abs 2505-653 bivalirudin heparin diabetes PCI pooled J Am Coll Cardiol 3.2009
Feit ACUITY diabetes bivalirudin JACC 4.2008
Feit diabetes 1-year meta-analysis REPLACE-2 ACUITY HORIZONS TCT 2009
Gurm REPLACE-2 bivalirudin diabetes JACC 6.05
Kario TF–induced coagulation endothelial Cell Dysfunction non-insulin-dependent diabetic microalbuminuria ATVB 1995
Kwaan blood coagulation platelet function plasminogen-plasmin system diabetes Diabetes1992
Ostermann hemostatic system diabetes Haemostasis 1986
Witzenbichler ACC abs 2506-558 bivalirudin diabetes AMI HORIZONS 3-year JACC 3 2011
Clopidogrel
Lincoff ACUITY bivalirudin clopidogrel JACC Int 12 2008
Safety
Bittl Am Heart J 2001
Cayla ABOARD NSTE-ACS bleeding Heart 3.2011
Giugliano EARLY ACS NEJM 5.2009
Jolly RIVAL radial femoral ACS Lancet 4 2011in press
Manoukian bivalirudin ACUITY bleeding 30-day mortality JACC 3.2007
Mehran bivalirudin risk score bleeding ACS JACC 6 2010wmMehran bivalirudin risk score bleeding ACS JACC 6 2010
Mehta OASIS-5 6-months JACC 10.2007
Minutello TCT Am J Cardiol 2003
Ndrepepa bleeding PCI quadruple JACC 2.2008
Stone bivalirudin ACUITY 30-day NEJM 11.06
Stone bivalirudin HORIZONS-AMI 30 Day NEJM 6.2008
SYNERGY Trial Invest enoxaparin heparin JAMA 7.2004
Verheugt bivalirudin access site bleeding PCI JACC Intervent 2 2011
Verheugt Steinhubl bivalirudin non-access bleeding pooled GISE 10 2009
Value
Pinto ACUITY economic bivalirudin J Am Coll Cardiol 11.2008
Olchanski costs bivalirudin PCI Hosp Pract (Minneap) 11 2010
Cohen bivalirudin economics REPLACE 2 JACC 11.04
Bajaj TCT-118 cost LOS bivalirudin Premier PCI JACC 9 2010
Bajaj bivalirudin cost LOS Premier poster TCT 2010.
Guidelines
ACC AHA PCI UA NSTEMI STEMI EACTS Revasc Guidelines 2011
Anderson ACC AHA Guidelines UA-NSTEMI full version Circ 8.2007
King ACC AHA PCI guidelines Circ 12 2007
Kohl guidelines myocardial revasc ESC EACTS EAPCI Eur J Cardio-thorac Surg 10.2010
Kushner ACC AHA Guidelines focused update PCI STEMI JACC 11 2009
Wijns ESC NSTEMI guidelines-revasc EHJ 10 2010
Important Safety Information
Angiox H-562-II-PI-EN
Angiomax PI - 12.06.2005
